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18 F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment.
- Source :
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Yonsei medical journal [Yonsei Med J] 2022 Mar; Vol. 63 (3), pp. 259-264. - Publication Year :
- 2022
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Abstract
- Purpose: Neuroinflammation is considered an important pathway associated with several diseases that result in cognitive decline. <superscript>18</superscript> F-THK5351 positron emission tomography (PET) signals might indicate the presence of neuroinflammation, as well as Alzheimer's disease-type tau aggregates. β-amyloid (Aβ)-negative (Aβ-) amnestic mild cognitive impairment (aMCI) may be associated with non-Alzheimer's disease pathophysiology. Accordingly, we investigated associations between <superscript>18</superscript> F-THK5351 PET positivity and cognitive decline among Aβ- aMCI patients.<br />Materials and Methods: The present study included 25 amyloid PET negative aMCI patients who underwent a minimum of two follow-up neuropsychological evaluations, including clinical dementia rating-sum of boxes (CDR-SOB). The patients were classified into two groups: <superscript>18</superscript> F-THK5351-positive and -negative groups. The present study used a linear mixed effects model to estimate the effects of <superscript>18</superscript> F-THK5351 PET positivity on cognitive prognosis among Aβ- aMCI patients.<br />Results: Among the 25 Aβ- aMCI patients, 10 (40.0%) were <superscript>18</superscript> F-THK5351 positive. The patients in the <superscript>18</superscript> F-THK5351-positive group were older than those in the <superscript>18</superscript> F-THK5351-negative group (77.4±2.2 years vs. 70.0±5.5 years; p <0.001). There was no difference between the two groups with regard to the proportion of apolipoprotein E ε4 carriers. Interestingly, however, the CDR-SOB scores of the <superscript>18</superscript> F-THK5351-positive group deteriorated at a faster rate than those of the <superscript>18</superscript> F-THK5351-negative group (B=0.003, p =0.033).<br />Conclusion: The results of the present study suggest that increased <superscript>18</superscript> F-THK5351 uptake might be a useful predictor of poor prognosis among Aβ- aMCI patients, which might be associated with increased neuroinflammation (ClinicalTrials.gov NCT02656498).<br />Competing Interests: The authors have no potential conflicts of interest to disclose.<br /> (© Copyright: Yonsei University College of Medicine 2022.)
Details
- Language :
- English
- ISSN :
- 1976-2437
- Volume :
- 63
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Yonsei medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 35184428
- Full Text :
- https://doi.org/10.3349/ymj.2022.63.3.259