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Drug Formulations for Localized Treatment of Human Papillomavirus-Induced Lesions.

Authors :
Maocha IG
Carvalho J
Lopes-Nunes J
Rosado T
Gallardo E
Tomás M
Palmeira-de-Oliveira A
Palmeira-de-Oliveira R
Martinez-de-Oliveira J
Campello MPC
Paulo A
Cruz C
Source :
Journal of pharmaceutical sciences [J Pharm Sci] 2022 Aug; Vol. 111 (8), pp. 2230-2238. Date of Electronic Publication: 2022 Feb 17.
Publication Year :
2022

Abstract

Background: The human papillomavirus (HPV) is responsible for over 90% of all cervical cancer cases. The use of vaginal gels is often indicated for local vaginal drug delivery. Previous studies have shown that Thymus vulgaris essential oil (TEO) exhibits anticancer properties besides antifungal and antibacterial properties. Its activity derives from a specific increase in free radicals and oxidative stress caused in cancer cells. Furthermore, mitoxantrone (MTX), an anthracenedione, and C <subscript>8</subscript> , an acridine orange derivative, were shown to inhibit the growth of the cervical cancer cell line HeLa.<br />Results: The results showed that TEO + C <subscript>8</subscript> is the most promising formulation in terms of viscosity and osmolality properties in vaginal fluid simulant (VFS). The combined action of TEO with the compounds MTX and C <subscript>8</subscript> resulted in HeLa cell viability reduction compared with the effect obtained with the individual formulations containing each one of the compounds.<br />Conclusions: The formulation TEO + C <subscript>8</subscript> holds promise in terms of cost-benefit and topical application of the active compound for the HeLa cells.<br />Competing Interests: Disclosure of Potential Conflicts of Interest No potential conflicts of interest were disclosed.<br /> (Copyright © 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1520-6017
Volume :
111
Issue :
8
Database :
MEDLINE
Journal :
Journal of pharmaceutical sciences
Publication Type :
Academic Journal
Accession number :
35182543
Full Text :
https://doi.org/10.1016/j.xphs.2022.02.004