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Effects of low-intensity training on the brain and muscle in the congenital muscular dystrophy 1D model.
- Source :
-
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2022 Jul; Vol. 43 (7), pp. 4493-4502. Date of Electronic Publication: 2022 Feb 19. - Publication Year :
- 2022
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Abstract
- Introduction: Congenital Muscular Dystrophy type 1D (MDC1D) is characterized by a hypoglycosylation of α-dystroglycan protein (α-DG), and this may be strongly implicated in increased skeletal muscle tissue degeneration and abnormal brain development, leading to cognitive impairment. However, the pathophysiology of brain involvement is still unclear. Low-intensity exercise training (LIET) is known to contribute to decreased muscle degeneration in animal models of other forms of progressive muscular dystrophies.<br />Aim: The objective of this study was to analyze the effects of LIET on cognitive involvement and oxidative stress in brain tissue and gastrocnemius muscle.<br />Methods: Male homozygous (Large <superscript>myd-/-</superscript> ), heterozygous (Large <superscript>myd+/-</superscript> ), and wild-type mice were used. To complete 28 days of life, they were subjected to a low-intensity exercise training (LIET) for 8 weeks. After the last day of training, 24 h were expected when the animals were submitted to inhibitory avoidance and open-field test. The striatum, prefrontal cortex, hippocampus, cortex, and gastrocnemius were collected for evaluation of protein carbonylation, lipid peroxidation, and catalase and superoxide dismutase activity.<br />Results: LIET was observed to reverse the alteration in aversive and habituation memory. Increased protein carbonylation in the striatum, prefrontal cortex, and hippocampus and lipid peroxidation in the prefrontal cortex and hippocampus were also reversed by LIET. In the evaluation of the antioxidant activity, LIET increased catalase activity in the hippocampus and cortex. In the gastrocnemius, LIET decreased the protein carbonylation and lipid peroxidation and increased catalase and superoxide dismutase activity.<br />Conclusion: In conclusion, it can be inferred that LIET for 8 weeks was able to reverse the cognitive damage and oxidative stress in brain tissue and gastrocnemius muscle in MDC1D animals.<br /> (© 2022. Fondazione Società Italiana di Neurologia.)
- Subjects :
- Animals
Catalase
Intellectual Disability
Male
Mice
Oxidative Stress physiology
Superoxide Dismutase genetics
Superoxide Dismutase metabolism
Brain metabolism
Brain physiopathology
Muscle, Skeletal metabolism
Muscle, Skeletal physiopathology
Muscular Dystrophies therapy
Physical Conditioning, Animal
Subjects
Details
- Language :
- English
- ISSN :
- 1590-3478
- Volume :
- 43
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 35182274
- Full Text :
- https://doi.org/10.1007/s10072-022-05928-w