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Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study.
- Source :
-
Respiratory research [Respir Res] 2022 Feb 17; Vol. 23 (1), pp. 34. Date of Electronic Publication: 2022 Feb 17. - Publication Year :
- 2022
-
Abstract
- Background: Whether restricted spirometry, i.e. low Forced Vital Capacity (FVC), predicts chronic cardiometabolic disease is not definitely known. In this international population-based study, we assessed the relationship between restricted spirometry and cardiometabolic comorbidities.<br />Methods: A total of 23,623 subjects (47.5% males, 19.0% current smokers, age: 55.1â±â10.8 years) from five continents (33 sites in 29 countries) participating in the Burden of Obstructive Lung Disease (BOLD) study were included. Restricted spirometry was defined as post-bronchodilator FVCâ<â5th percentile of reference values. Self-reports of physician-diagnosed cardiovascular disease (CVD; heart disease or stroke), hypertension, and diabetes were obtained through questionnaires.<br />Results: Overall 31.7% of participants had restricted spirometry. However, prevalence of restricted spirometry varied approximately ten-fold, and was lowest (8.5%) in Vancouver (Canada) and highest in Sri Lanka (81.3%). Crude odds ratios for the association with restricted spirometry were 1.60 (95% CI 1.37-1.86) for CVD, 1.53 (95% CI 1.40-1.66) for hypertension, and 1.98 (95% CI 1.71-2.29) for diabetes. After adjustment for age, sex, education, Body Mass Index (BMI) and smoking, the odds ratios were 1.54 (95% CI 1.33-1.79) for CVD, 1.50 (95% CI 1.39-1.63) for hypertension, and 1.86 (95% CI 1.59-2.17) for diabetes.<br />Conclusion: In this population-based, international, multi-site study, restricted spirometry associates with cardiometabolic diseases. The magnitude of these associations appears unattenuated when cardiometabolic risk factors are taken into account.<br /> (© 2022. The Author(s).)
- Subjects :
- Cardiovascular Diseases physiopathology
Comorbidity
Europe epidemiology
Female
Humans
Incidence
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive diagnosis
Pulmonary Disease, Chronic Obstructive physiopathology
Cardiovascular Diseases epidemiology
Forced Expiratory Volume physiology
Lung physiopathology
Pulmonary Disease, Chronic Obstructive epidemiology
Spirometry methods
Vital Capacity physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-993X
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Respiratory research
- Publication Type :
- Academic Journal
- Accession number :
- 35177082
- Full Text :
- https://doi.org/10.1186/s12931-022-01939-5