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Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group.
- Source :
-
Frontiers in immunology [Front Immunol] 2022 Jan 31; Vol. 12, pp. 766278. Date of Electronic Publication: 2022 Jan 31 (Print Publication: 2021). - Publication Year :
- 2022
-
Abstract
- CoronaVac vaccine from Sinovac Life Science is currently being used in several countries. In Chile, the effectiveness of preventing hospitalization is higher than 80% with a vaccination schedule. However, to date, there are no data about immune response induction or specific memory. For this reason, we recruited 15 volunteers without previous suspected/diagnosed COVID-19 and with negative PCR over time to evaluate the immune response to CoronaVac 28 and 90 days after the second immunization (dpi). The CoronaVac administration induces total and neutralizing anti-spike antibodies in all vaccinated volunteers at 28 and 90 dpi. Furthermore, using ELISpot analysis to assay cellular immune responses against SARS-CoV-2 spike protein, we found an increase in IFN-gamma- and Granzyme B-producing cells in vaccinated volunteers at 28 and 90 dpi. Together, our results indicate that CoronaVac induces a robust humoral immune response and cellular immune memory of at least 90 dpi.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Escobar, Reyes-López, Acevedo, Alonso-Palomares, Valiente-Echeverría, Soto-Rifo, Portillo, Gatica, Flores, Nova-Lamperti, Barrera-Avalos, Bono, Vargas, Simon, Leiva-Salcedo, Vial, Hormazabal, Cortes, Valdés, Sandino, Imarai and Acuña-Castillo.)
- Subjects :
- Adult
B-Lymphocytes immunology
B-Lymphocytes metabolism
Biomarkers blood
COVID-19 immunology
COVID-19 virology
COVID-19 Vaccines immunology
Chile
Female
Granzymes metabolism
Healthy Volunteers
Humans
Immunity, Cellular drug effects
Immunity, Humoral drug effects
Immunologic Memory drug effects
Interferon-gamma metabolism
Male
Middle Aged
Spike Glycoprotein, Coronavirus immunology
Time Factors
Treatment Outcome
Antibodies, Neutralizing blood
Antibodies, Viral blood
B-Lymphocytes drug effects
COVID-19 prevention & control
COVID-19 Vaccines administration & dosage
Immunization Schedule
Immunogenicity, Vaccine
SARS-CoV-2 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 35173705
- Full Text :
- https://doi.org/10.3389/fimmu.2021.766278