Back to Search
Start Over
Brain-wide visual habituation networks in wild type and fmr1 zebrafish.
- Source :
-
Nature communications [Nat Commun] 2022 Feb 16; Vol. 13 (1), pp. 895. Date of Electronic Publication: 2022 Feb 16. - Publication Year :
- 2022
-
Abstract
- Habituation is a form of learning during which animals stop responding to repetitive stimuli, and deficits in habituation are characteristic of several psychiatric disorders. Due to technical challenges, the brain-wide networks mediating habituation are poorly understood. Here we report brain-wide calcium imaging during larval zebrafish habituation to repeated visual looming stimuli. We show that different functional categories of loom-sensitive neurons are located in characteristic locations throughout the brain, and that both the functional properties of their networks and the resulting behavior can be modulated by stimulus saliency and timing. Using graph theory, we identify a visual circuit that habituates minimally, a moderately habituating midbrain population proposed to mediate the sensorimotor transformation, and downstream circuit elements responsible for higher order representations and the delivery of behavior. Zebrafish larvae carrying a mutation in the fmr1 gene have a systematic shift toward sustained premotor activity in this network, and show slower behavioral habituation.<br /> (© 2022. The Author(s).)
- Subjects :
- Animals
Animals, Genetically Modified
Brain Waves physiology
Calcium analysis
Larva physiology
Neurons physiology
RNA-Binding Proteins genetics
Reflex, Startle physiology
Zebrafish embryology
Zebrafish Proteins genetics
Habituation, Psychophysiologic physiology
Mesencephalon physiology
RNA-Binding Proteins metabolism
Zebrafish physiology
Zebrafish Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 35173170
- Full Text :
- https://doi.org/10.1038/s41467-022-28299-4