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Primary plasma cell leukemias displaying t(11;14) have specific genomic, transcriptional, and clinical features.

Authors :
Cazaubiel T
Leleu X
Perrot A
Manier S
Buisson L
Maheo S
Do Souto Ferreira L
Lannes R
Pavageau L
Hulin C
Marolleau JP
Voillat L
Belhadj K
Divoux M
Slama B
Brechignac S
Macro M
Stoppa AM
Sanhes L
Orsini-Piocelle F
Fontan J
Chretien ML
Demarquette H
Mohty M
Schavgoulidze A
Avet-Loiseau H
Corre J
Source :
Blood [Blood] 2022 Apr 28; Vol. 139 (17), pp. 2666-2672.
Publication Year :
2022

Abstract

Primary plasma cell leukemia (pPCL) is an aggressive form of multiple myeloma (MM) that has not benefited from recent therapeutic advances in the field. Because it is very rare and heterogeneous, it remains poorly understood at the molecular level. To address this issue, we performed DNA and RNA sequencing of sorted plasma cells from a large cohort of 90 newly diagnosed pPCL and compared with MM. We observed that pPCL presents a specific genomic landscape with a high prevalence of t(11;14) (about half) and high-risk genomic features such as del(17p), gain 1q, and del(1p32). In addition, pPCL displays a specific transcriptome when compared with MM. We then wanted to characterize specifically pPCL with t(11;14). We observed that this subentity displayed significantly fewer adverse cytogenetic abnormalities. This translated into better overall survival when compared with pPCL without t(11;14) (39.2 months vs 17.9 months, P = .002). Finally, pPCL with t(11;14) displayed a specific transcriptome, including differential expression of BCL2 family members. This study is the largest series of patients with pPCL reported so far.<br /> (© 2022 by The American Society of Hematology.)

Details

Language :
English
ISSN :
1528-0020
Volume :
139
Issue :
17
Database :
MEDLINE
Journal :
Blood
Publication Type :
Academic Journal
Accession number :
35171994
Full Text :
https://doi.org/10.1182/blood.2021014968