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Mineralized Polyvinyl Alcohol/Sodium Alginate Hydrogels Incorporating Cellulose Nanofibrils for Bone and Wound Healing.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 21; Vol. 27 (3). Date of Electronic Publication: 2022 Jan 21. - Publication Year :
- 2022
-
Abstract
- Bio sustainable hydrogels including tunable morphological and/or chemical cues currently offer a valid strategy of designing innovative systems to enhance healing/regeneration processes of damaged tissue areas. In this work, TEMPO-oxidized cellulose nanofibrils (T-CNFs) were embedded in alginate (Alg) and polyvinyl alcohol (PVA) solution to form a stable mineralized hydrogel. A calcium chloride reaction was optimized to trigger a crosslinking reaction of polymer chains and mutually promote in situ mineralization of calcium phosphates. FTIR, XRD, SEM/EDAX, and TEM were assessed to investigate the morphological, chemical, and physical properties of different mineralized hybrid hydrogels, confirming differences in the deposited crystalline nanostructures, i.e., dicalcium phosphate dehydrate (DCPDH) and hydroxyapatite, respectively, as a function of applied pH conditions (i.e., pH 4 or 8). Moreover, in vitro tests, in the presence of HFB-4 and HSF skin cells, confirmed a low cytotoxicity of the mineralized hybrid hydrogels, and also highlighted a significant increase in cell viability via MTT tests, preferentially, for the low concentration, crosslinked Alg/PVA/calcium phosphate hybrid materials (<1 mg/mL) in the presence of hydroxyapatite. These preliminary results suggest a promising use of mineralized hybrid hydrogels based on Alg/PVA/T-CNFs for bone and wound healing applications.
- Subjects :
- Alginates chemistry
Bone and Bones drug effects
Bone and Bones metabolism
Calcium Phosphates chemistry
Cellulose chemistry
Cellulose pharmacology
Cellulose, Oxidized
Durapatite chemistry
Fibroblasts drug effects
Humans
Hydrogels
Nanofibers therapeutic use
Polyvinyl Alcohol chemistry
Tissue Engineering methods
Wound Healing physiology
Alginates pharmacology
Polyvinyl Alcohol pharmacology
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 35163962
- Full Text :
- https://doi.org/10.3390/molecules27030697