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Prognostic Value of Immunohistochemical Markers for Locally Advanced Rectal Cancer.

Authors :
Taha A
Taha-Mehlitz S
Petzold S
Achinovich SL
Zinovkin D
Enodien B
Pranjol MZI
Nadyrov EA
Source :
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 18; Vol. 27 (3). Date of Electronic Publication: 2022 Jan 18.
Publication Year :
2022

Abstract

The aim of this study is to reveal the potential roles of apoptosis markers (Bcl2 and p53), proliferation markers (Ki-67 and CyclD1), and the neuroendocrine marker Chromogranin A as markers for the radioresistance of rectal cancer. Statistically significant differences were found in the expression of p53, Ki-67, and Chromogranin A in groups of patients with and without a favorable prognosis after radiotherapy. The survival analysis revealed that the marker of neuroendocrine differentiation, Chromogranin A, also demonstrated a high prognostic significance, indicating a poor prognosis. Markers of proliferation and apoptosis had no prognostic value for patients who received preoperative radiotherapy. Higher Chromogranin A values were predictors of poor prognosis. The results obtained from studying the Chromogranin A expression suggest that the secretion of biologically active substances by neuroendocrine cells causes an increase in tumor aggressiveness.

Details

Language :
English
ISSN :
1420-3049
Volume :
27
Issue :
3
Database :
MEDLINE
Journal :
Molecules (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
35163861
Full Text :
https://doi.org/10.3390/molecules27030596