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Prognostic Value of Immunohistochemical Markers for Locally Advanced Rectal Cancer.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 18; Vol. 27 (3). Date of Electronic Publication: 2022 Jan 18. - Publication Year :
- 2022
-
Abstract
- The aim of this study is to reveal the potential roles of apoptosis markers (Bcl2 and p53), proliferation markers (Ki-67 and CyclD1), and the neuroendocrine marker Chromogranin A as markers for the radioresistance of rectal cancer. Statistically significant differences were found in the expression of p53, Ki-67, and Chromogranin A in groups of patients with and without a favorable prognosis after radiotherapy. The survival analysis revealed that the marker of neuroendocrine differentiation, Chromogranin A, also demonstrated a high prognostic significance, indicating a poor prognosis. Markers of proliferation and apoptosis had no prognostic value for patients who received preoperative radiotherapy. Higher Chromogranin A values were predictors of poor prognosis. The results obtained from studying the Chromogranin A expression suggest that the secretion of biologically active substances by neuroendocrine cells causes an increase in tumor aggressiveness.
- Subjects :
- Adenocarcinoma metabolism
Adenocarcinoma radiotherapy
Adult
Aged
Chromogranin A metabolism
Cyclin D1 metabolism
Female
Follow-Up Studies
Humans
Ki-67 Antigen metabolism
Male
Middle Aged
Neuroendocrine Cells metabolism
Prognosis
Proto-Oncogene Proteins c-bcl-2 metabolism
Rectal Neoplasms metabolism
Rectal Neoplasms radiotherapy
Survival Rate
Tumor Suppressor Protein p53 metabolism
Adenocarcinoma pathology
Biomarkers, Tumor metabolism
Immunohistochemistry methods
Neuroendocrine Cells pathology
Rectal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 35163861
- Full Text :
- https://doi.org/10.3390/molecules27030596