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Pregnant and Postpartum Women Requiring Intensive Care Treatment for COVID-19-First Data from the CRONOS-Registry.

Authors :
Sitter M
Pecks U
Rüdiger M
Friedrich S
Fill Malfertheiner S
Hein A
Königbauer JT
Becke-Jakob K
Zöllkau J
Ramsauer B
Rathberger K
Pontones CA
Kraft K
Meybohm P
Härtel C
Kranke P
Cronos Network
Source :
Journal of clinical medicine [J Clin Med] 2022 Jan 28; Vol. 11 (3). Date of Electronic Publication: 2022 Jan 28.
Publication Year :
2022

Abstract

(1) Background: Data on coronavirus 2 infection during pregnancy vary. We aimed to describe maternal characteristics and clinical presentation of SARS-CoV-2 positive women requiring intensive care treatment for COVID-19 during pregnancy and postpartum period based on data of a comprehensive German surveillance system in obstetric patients. (2) Methods: Data from COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS), a prospective multicenter registry for SARS-CoV-2 positive pregnant women, was analyzed with respect to ICU treatment. All women requiring intensive care treatment for COVID-19 were included and compared regarding maternal characteristics, course of disease, as well as maternal and neonatal outcomes. (3) Results: Of 2650 cases in CRONOS, 101 women (4%) had a documented ICU stay. Median maternal age was 33 (IQR, 30-36) years. COVID-19 was diagnosed at a median gestational age of 33 (IQR, 28-35) weeks. As the most invasive form of COVID-19 treatment interventions, patients received either continuous monitoring of vital signs without further treatment requirement ( n = 6), insufflation of oxygen ( n = 30), non-invasive ventilation ( n = 22), invasive ventilation ( n = 28), or escalation to extracorporeal membrane oxygenation ( n = 15). No significant clinical differences were identified between patients receiving different forms of ventilatory support for COVID-19. Prevalence of preterm delivery was significantly higher in women receiving invasive respiratory treatments. Four women died of COVID-19 and six fetuses were stillborn. (4) Conclusions: Our cohort shows that progression of COVID-19 is rare in pregnant and postpartum women treated in the ICU. Preterm birth rate is high and COVID-19 requiring respiratory support increases the risk of poor maternal and neonatal outcome.

Details

Language :
English
ISSN :
2077-0383
Volume :
11
Issue :
3
Database :
MEDLINE
Journal :
Journal of clinical medicine
Publication Type :
Academic Journal
Accession number :
35160161
Full Text :
https://doi.org/10.3390/jcm11030701