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Correction by insulin of disturbed TG-rich LP metabolism in rats with chronic renal failure.
- Source :
-
The American journal of physiology [Am J Physiol] 1986 Apr; Vol. 250 (4 Pt 1), pp. E373-6. - Publication Year :
- 1986
-
Abstract
- To define the role of insulin in lipid disturbances of chronic renal failure, chronically uremic rats (U+) were supplemented by continuous insulin infusion over a 35-day experimental period and compared with control ad libitum-fed rats (C) and uremic rats without insulin (U). Uremic rats were characterized by hypoinsulinemia, an increase in both circulating very low-density lipoprotein (VLDL) and their cholesterol concentration, a normal hepatic triglyceride secretion rate (TGSR) determined with Triton WR 1339, and a low adipose tissue lipoprotein lipase (LPL) activity. Chronic insulin infusion at low rate (0.5 IU/24 h) to U+ rats normalized serum insulin (from 17.0 +/- 0.6 mU/l in U rats to 23.4 +/- 1.7 mU/l in U+ rats), serum VLDL triglycerides (from 804 +/- 65 to 410 +/- 36 mg/l), and serum VLDL cholesterol (from 43 +/- 8 to 16 +/- 3 mg/l). Hepatic TGSR decreased significantly after insulin treatment (from 0.58 +/- 0.03 to 0.44 +/- 0.03 mumol/min). Moreover, adipose tissue LPL was restored to normal by insulin supplementation (from 460 +/- 60 to 860 +/- 150 mU per total epididymal fat in U and U+ rats, respectively). Correction of the disturbed VLDL metabolism was associated with multiple actions of insulin including 1) a decrease of peripheral lipolysis, 2) a decrease of hepatic TGSR, and 3) an increase of adipose tissue LPL activity. Because cholesterol-rich VLDL are potentially atherogenic, their normalization with insulin treatment in this animal model suggests a viable area of investigation for the prevention of accelerated atherogenesis in chronic renal failure.
- Subjects :
- Adipose Tissue enzymology
Animals
Apolipoproteins blood
Blood Glucose analysis
Cholesterol blood
Cholesterol, VLDL
Fatty Acids, Nonesterified blood
Insulin blood
Lactates blood
Lactic Acid
Lipoprotein Lipase metabolism
Male
Phospholipids blood
Rats
Rats, Inbred Strains
Uremia blood
Insulin pharmacology
Kidney Failure, Chronic blood
Lipoproteins, VLDL blood
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9513
- Volume :
- 250
- Issue :
- 4 Pt 1
- Database :
- MEDLINE
- Journal :
- The American journal of physiology
- Publication Type :
- Academic Journal
- Accession number :
- 3515962
- Full Text :
- https://doi.org/10.1152/ajpendo.1986.250.4.E373