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Biological Activities, Pharmacokinetics and Toxicity of Nootkatone: A Review.

Authors :
Jha AK
Gairola S
Kundu S
Doye P
Syed AM
Ram C
Kulhari U
Kumar N
Murty US
Sahu BD
Source :
Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2022; Vol. 22 (17), pp. 2244-2259.
Publication Year :
2022

Abstract

Plant-based drugs have a significant impact on modern therapeutics due to their vast array of pharmacological activities. The integration of herbal plants in the current healthcare system has emerged as a new field of research. It can be used for the identification of novel lead compound candidates for future drug development. Nootkatone is a sesquiterpene derivative and an isolate of grapefruit. Shreds of evidence illustrate that nootkatone targets few molecular mechanisms to exhibit its pharmacological activity and yet needs more exploration. The current review is related to nootkatone, drafted through a literature search using research articles and books from different sources, including Science Direct, Google Scholar, Elsevier, PubMed, and Scopus. It has been reported to possess a wide range of pharmacological activities such as anti-inflammatory, anticancer, antibacterial, hepatoprotective, neuroprotective, and cardioprotective. Although preclinical studies in experimental animal models suggest that nootkatone has therapeutic potential, it is further warranted to evaluate its toxicity and pharmacokinetic parameters before being applied to humans. Hence, in the present review, we have summarized the scientific knowledge on nootkatone with a particular emphasis on its pharmacological properties to encourage researchers for further exploration in preclinical and clinical settings.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Details

Language :
English
ISSN :
1875-5607
Volume :
22
Issue :
17
Database :
MEDLINE
Journal :
Mini reviews in medicinal chemistry
Publication Type :
Academic Journal
Accession number :
35156582
Full Text :
https://doi.org/10.2174/1389557522666220214092005