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The potential of long noncoding RNA therapies.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2022 Apr; Vol. 43 (4), pp. 269-280. Date of Electronic Publication: 2022 Feb 10. - Publication Year :
- 2022
-
Abstract
- The human genome expresses vast numbers of long noncoding RNAs (lncRNA) that fulfil diverse roles in gene regulation, cell biology, development, and human disease. These roles are often mediated by sequence motifs and secondary structures bound by proteins and can regulate epigenetic, transcriptional, and translational pathways. These functional domains can be further optimised and engineered into RNA devices that are widely used in synthetic biology. We propose that natural lncRNA structures can be explored and exploited for the rational design and assembly of synthetic RNA therapies. This potential has been enabled by advances in the stability, immunogenicity, manufacture, and delivery of other RNA-based therapies, from which we can anticipate the pharmacological properties of lncRNA therapies that have not yet otherwise entered clinical trials.<br /> (Crown Copyright © 2022. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Gene Expression Regulation
Genome, Human
Humans
RNA, Long Noncoding genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3735
- Volume :
- 43
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35153075
- Full Text :
- https://doi.org/10.1016/j.tips.2022.01.008