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In vitro α-glucosidase inhibition by Brazilian medicinal plant extracts characterised by ultra-high performance liquid chromatography coupled to mass spectrometry.
- Source :
-
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 554-562. - Publication Year :
- 2022
-
Abstract
- Aiming at finding natural sources of antidiabetics agents, 15 extracts from Brazilian medicinal plants of the Atlantic Forest and Amazon region were tested against α-glucosidase enzyme. Plants were selected based on the taxonomic relationships with genera including several species with antidiabetic activity. In this screening, the extracts obtained from the flowers of Hyptis monticola and the leaves of Lantana trifolia and Lippia origanoides resulted endowed with promising anti-α-glucosidase activity. The extracts from H. monticola and from L. origanoides collected in two different areas, were characterised by ultra-high performance liquid chromatography coupled to mass spectrometry. Bioassay-guided fractionation led to the identification of several enzyme inhibiting compounds, among them the mechanism of action of naringenin and pinocembrin was investigated. The two L. origanoides extracts showed differences in bioactivity and in the phytochemical profiles. The fractionation of the extract from H. monticola led to a partial loss of the inhibitory effect.
- Subjects :
- Brazil
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Flowers chemistry
Glycoside Hydrolase Inhibitors chemistry
Glycoside Hydrolase Inhibitors isolation & purification
Mass Spectrometry
Molecular Structure
Plant Extracts chemistry
Plant Extracts isolation & purification
Plant Leaves chemistry
Saccharomyces cerevisiae enzymology
Structure-Activity Relationship
Glycoside Hydrolase Inhibitors pharmacology
Hyptis chemistry
Lantana chemistry
Plant Extracts pharmacology
Plants, Medicinal chemistry
alpha-Glucosidases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1475-6374
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of enzyme inhibition and medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 35152818
- Full Text :
- https://doi.org/10.1080/14756366.2021.2022658