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Gastroprotective effect of Berberis vulgaris on ethanol-induced gastric mucosal injury: Histopathological evaluations.
- Source :
-
Avicenna journal of phytomedicine [Avicenna J Phytomed] 2022 Jan-Feb; Vol. 12 (1), pp. 30-41. - Publication Year :
- 2022
-
Abstract
- Objective: Modern treatment of peptic ulcers includes antibacterial and gastroprotective medications. However, current anti-ulcer drugs possess severe side effects. Therefore, all attempts to find new effective medications free from side effects are justified. Though Berberis vulgaris is a medicinal plant commonly used for the treatment of numerous disorders, gastroprotective effect of its leaf extract was not investigated before.<br />Materials and Methods: Gastric ulcer was modelled in Sprague-Dawley rats after treatment with B. vulgaris leaf extract containing 0.07% of alkaloids, 0.48% of flavonoids and 8.05% of tanning substances, 10 or 50 mg of dry extract/kg, changes in the stomach mucosa were assessed semi-quantitatively, and the gastric wall was evaluated for prostaglandin E2 level using ELISA and assessed histologically by calculation of the lesion index.<br />Results: B. vulgaris leaf extract at the dose of 50 mg/kg reduced the macroscopic ulcer score and the microscopic lesion index, increased prostaglandin E2 concentration in the gastric wall significantly higher than atropine and B. vulgaris leaf extract 10 mg/kg.<br />Conclusion: The gastroprotective effect of the high dose of B. vulgaris leaf extract may be due to stimulation of prostaglandin E2 secretion in the stomach, and anti-oxidative and anti-inflammatory properties of polyphenolic complex of flavonoids and tannins present in the leaves of this plant.<br />Competing Interests: The authors have declared that there is no conflict of interest.
Details
- Language :
- English
- ISSN :
- 2228-7930
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Avicenna journal of phytomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 35145893
- Full Text :
- https://doi.org/10.22038/AJP.2021.18113