Anti-tumor alkaloids from Peganum harmala.

Authors :: Zhang Q
Zan YH
Yang HG
Yang MY
Liu FS
Li SG
Peng XH
Lin B
Li ZL
Li DH
Hua HM
Source :: Phytochemistry [Phytochemistry] 2022 May; Vol. 197, pp. 113107. Date of Electronic Publication: 2022 Feb 01.
Publication Year :: 2022
Abstract: Six alkaloids peharmalines F-K, along with 14 known ones, were isolated from the aerial part of Peganum harmala L.. The structures of the isolated compounds were determined based on their HR-ESI-MS data, extensive NMR spectroscopic analyses, and ECD calculations. 3-(4-Hydroxyphenyl)quinoline exhibited potent antiproliferative activity against the HepG-2 cell lines with an IC <subscript>50</subscript> value of 3.05 μM. Norharmane displayed a moderate inhibition against A549 and HepG-2 cells with IC <subscript>50</subscript> values of 16.45 μM and 17.27 μM, respectively.<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)