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Photoswitchable inhibitors of human β-glucocerebrosidase.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Feb 23; Vol. 20 (8), pp. 1637-1641. Date of Electronic Publication: 2022 Feb 23. - Publication Year :
- 2022
-
Abstract
- Light-switchable inhibitors of the enzyme β-glucocerebrosidase (GCase) have been developed by anchoring a specific azasugar to a dihydroazulene or an azobenzene responsive moiety. Their inhibitory effect towards human GCase, before and after irradiation are reported, and the effect on thermal denaturation of recombinant GCase and cytotoxicity were studied on selected candidates.
- Subjects :
- Azo Compounds chemical synthesis
Azo Compounds chemistry
Azulenes chemical synthesis
Azulenes chemistry
Cell Line
Cell Survival drug effects
Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors chemistry
Glucosylceramidase metabolism
Humans
Light
Molecular Structure
Photochemical Processes
Azo Compounds pharmacology
Azulenes pharmacology
Enzyme Inhibitors pharmacology
Glucosylceramidase antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 20
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 35107482
- Full Text :
- https://doi.org/10.1039/d1ob02159a