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Effects of real-ambient PM 2.5 exposure plus lipopolysaccharide on multiple organ damage in mice.
- Source :
-
Human & experimental toxicology [Hum Exp Toxicol] 2022 Jan-Dec; Vol. 41, pp. 9603271211061505. - Publication Year :
- 2022
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Abstract
- Background: The toxicological effects of fine particulate matter (PM <subscript>2.5</subscript> ) on the cardiopulmonary and nervous systems have been studied widely, whereas the study of PM <subscript>2.5</subscript> on systemic toxicity is not in-depth enough. Lipopolysaccharide (LPS) can cause multiple organ damage. The combined effects of co-exposure of PM <subscript>2.5</subscript> plus LPS on the stomach, spleen, intestine, and kidney are still unclear. Purpose: This study was aimed to explore the toxicological effects of co-exposure of PM <subscript>2.5</subscript> and LPS on the different organs of mice. Research Design and Study Sample Using a real-ambient PM <subscript>2.5</subscript> exposure system and an intraperitoneal LPS injection mouse model, we investigated multiple organ damage effects on male BALB/c mice after co-exposure of PM <subscript>2.5</subscript> plus LPS for 23 weeks in Linfen, a city with a high PM <subscript>2.5</subscript> concentration in China. Data Collection: Eosin-hematoxylin staining, ELISA and the biochemical assay analysed the toxicological effects. Results: The pathological tissue injury on the four organs above appeared in mice co-exposed to PM <subscript>2.5</subscript> plus LPS, accompanied by the body weight and stomach organ coefficient abnormality, and significant elevation of pro-inflammatory cytokines levels, oxidative stress in the spleen and kidney, and levels of kidney injury molecule (KIM-1) increase in the kidney. There were tissue differences in the pathological damage and toxicological effects on mice after co-exposure, in which the spleen and kidney were more sensitive to pollutants. In the PM <subscript>2.5</subscript> + LPS group, the superoxide dismutase inhibition and catalase (CAT) activity promotion in the kidney or spleen of mice were significant relative to the PM <subscript>2.5</subscript> group; the CAT and interleukin-6 (IL-6) levels in the spleen were raised considerably compared with the LPS group. Conclusions: These findings suggested the severity and sensitivity of multiple organ injuries in mice in response to PM <subscript>2.5</subscript> plus LPS.
- Subjects :
- Animals
China
Disease Models, Animal
Humans
Intestinal Diseases physiopathology
Kidney Diseases physiopathology
Male
Mice
Mice, Inbred BALB C
Splenic Diseases physiopathology
Stomach Diseases physiopathology
Intestinal Diseases chemically induced
Kidney Diseases chemically induced
Lipopolysaccharides toxicity
Multiple Organ Failure chemically induced
Multiple Organ Failure physiopathology
Particulate Matter toxicity
Splenic Diseases chemically induced
Stomach Diseases chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0903
- Volume :
- 41
- Database :
- MEDLINE
- Journal :
- Human & experimental toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 35098763
- Full Text :
- https://doi.org/10.1177/09603271211061505