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Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19.
- Source :
-
Hematology, transfusion and cell therapy [Hematol Transfus Cell Ther] 2022 Apr-Jun; Vol. 44 (2), pp. 235-245. Date of Electronic Publication: 2022 Jan 25. - Publication Year :
- 2022
-
Abstract
- Introduction: The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences.<br />Objective: Although the management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology.<br />Method and Results: Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death.<br />Conclusion: The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence.<br />Competing Interests: The authors declare no conflicts of interest.<br /> (© 2022 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier España, S.L.U.)
Details
- Language :
- English
- ISSN :
- 2531-1387
- Volume :
- 44
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Hematology, transfusion and cell therapy
- Publication Type :
- Academic Journal
- Accession number :
- 35098037
- Full Text :
- https://doi.org/10.1016/j.htct.2022.01.005