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Multigram Synthesis of Advanced 6,6-Difluorospiro[3.3]heptane-derived Building Blocks.
- Source :
-
European journal of organic chemistry [European J Org Chem] 2021 Dec 21; Vol. 2021 (47), pp. 6541-6550. Date of Electronic Publication: 2020 Apr 25. - Publication Year :
- 2021
-
Abstract
- A convenient methodology for constructing 6,6-difluorospiro[3.3]heptane scaffold - a conformationally restricted isostere of gem -difluorocycloalkanes - is developed. Alarge array of novel 2-mono- and 2,2-bifunctionalized difluorospiro[3.3]heptane building blocks was obtained through the convergent synthesis strategy using a common synthetic precursor - 1,1-bis(bromomethyl)-3,3-difluorocyclobutane. The target compounds and intermediates were prepared by short reaction sequences (6-10 steps) on multigram scale (up to 0.47 kg).
Details
- Language :
- English
- ISSN :
- 1434-193X
- Volume :
- 2021
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- European journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 35095338
- Full Text :
- https://doi.org/10.1002/ejoc.202000432