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Bioactive lipids from the fruits of Solanum xanthocarpum and their anti-inflammatory activities.
- Source :
-
Fitoterapia [Fitoterapia] 2022 Mar; Vol. 157, pp. 105134. Date of Electronic Publication: 2022 Jan 24. - Publication Year :
- 2022
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Abstract
- Bioactive lipids widely found in daily consumed plants and animals are essential or beneficial to health and some of them are important physiological regulators in the human body. In our current investigation, 18 bioactive lipids (1-18), including 8 sphingolipids (1-8), 7 oxylipins (9-15), 3 phenolic lipids (16-18) were isolated from the fruits of Solanum xanthocarpum. And compounds 1, 9, 15, 16, and 18 were new lipids. In this study, homologues (4-8, 16, and 17) and configuration isomers (2 and 3) of bioactive lipids were separated, and NMR combined with MS/MS <superscript>2</superscript> was an effective method to identify these compounds. These findings provided the reference for the separation and structural identification of bioactive lipids. The anti-inflammatory activities of all isolated lipids were evaluated by their inhibition of the NO release of LPS-induced RAW 264.7 cells. Aglycone components of sphingolipids, oxylipids with free carboxylic acid groups, phenylpropionic acid-fatty acid glyceride polymer exhibited significant anti-inflammatory activities. Further analysis by molecular docking revealed the interactions of bioactive compounds with the iNOS protein.<br /> (Copyright © 2022. Published by Elsevier B.V.)
- Subjects :
- Animals
Anti-Inflammatory Agents chemistry
Gas Chromatography-Mass Spectrometry
Hydrolysis
Inhibitory Concentration 50
Lipids chemistry
Magnetic Resonance Spectroscopy
Mice
Molecular Docking Simulation
Molecular Structure
Oxylipins chemistry
Oxylipins pharmacology
Phenols chemistry
Phenols pharmacology
Phytochemicals chemistry
RAW 264.7 Cells
Sphingolipids chemistry
Sphingolipids pharmacology
Tandem Mass Spectrometry
Anti-Inflammatory Agents pharmacology
Fruit chemistry
Lipids pharmacology
Phytochemicals pharmacology
Solanum chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 157
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 35085725
- Full Text :
- https://doi.org/10.1016/j.fitote.2022.105134