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Metal-Organic Polyhedron with Four Fe(III) Centers Producing Enhanced T 1 Magnetic Resonance Imaging Contrast in Tumors.
- Source :
-
Inorganic chemistry [Inorg Chem] 2022 Feb 07; Vol. 61 (5), pp. 2603-2611. Date of Electronic Publication: 2022 Jan 24. - Publication Year :
- 2022
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Abstract
- A metal-organic polyhedron (MOP) with four paramagnetic Fe(III) centers was studied as a magnetic resonance imaging (MRI) probe. The MOP was characterized in solution by using electron paramagnetic resonance (EPR), UV-visible (UV-vis) spectroscopies, Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry, and in the solid state with single-crystal X-ray diffraction. Water proton T <subscript>1</subscript> relaxation properties were examined in solution and showed significant enhancement in the presence of human serum albumin (HSA). The r <subscript>1</subscript> relaxivities in the absence and presence of HSA were 8.7 mM <superscript>-1</superscript> s <superscript>-1</superscript> and 21 mM <superscript>-1</superscript> s <superscript>-1</superscript> , respectively, per molecule (2.2 mM <superscript>-1</superscript> s <superscript>-1</superscript> and 5.3 mM <superscript>-1</superscript> s <superscript>-1</superscript> per Fe) at 4.7 T, 37 °C. In vivo studies of the iron MOP show strong contrast enhancement of the blood pool even at a low dose of 0.025 mmol/kg with prolonged residence in vasculature and clearance through the intestinal tract of mice. The MOP binds strongly to serum albumin and shows comparable accumulation in a murine tumor model as compared to a covalently linked Gd-HSA contrast agent.
Details
- Language :
- English
- ISSN :
- 1520-510X
- Volume :
- 61
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Inorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 35073060
- Full Text :
- https://doi.org/10.1021/acs.inorgchem.1c03660