Current status of non-surgical treatment of locally advanced pancreatic cancer.

Authors :: Spiliopoulos S
Zurlo MT
Casella A
Laera L
Surico G
Surgo A
Fiorentino A
de'Angelis N
Calbi R
Memeo R
Inchingolo R
Source :: World journal of gastrointestinal oncology [World J Gastrointest Oncol] 2021 Dec 15; Vol. 13 (12), pp. 2064-2075.
Publication Year :: 2021
Abstract: Pancreatic cancer is the 7 <superscript>th</superscript> leading cause of death due to cancer in industrialized countries and the 11 <superscript>th</superscript> most common cancer globally, with 458918 new cases (2.5% of all cancers) and 432242 deaths (4.5% of all cancer deaths) in 2018. Unfortunately, 80% to 90% of the patients present with unresectable disease, and the reported 5-year survival rate range between 10% and 25%, even after successful resection with tumor-free margins. Systemic chemotherapy, radiotherapy, and minimally invasive image-guided procedures that have emerged over the past years, are used for the management of non-operable PC. This review focuses on currently available non-surgical options of locally advanced pancreatic cancer.<br />Competing Interests: Conflict-of-interest statement: The authors state that they have no conflicts of interest.<br /> (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)