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Treadmill training attenuate STZ-induced cognitive dysfunction in type 2 diabetic rats via modulating Grb10/IGF-R signaling.
- Source :
-
Brain research bulletin [Brain Res Bull] 2022 Apr; Vol. 181, pp. 12-20. Date of Electronic Publication: 2022 Jan 20. - Publication Year :
- 2022
-
Abstract
- Type 2 diabetes is a major factor contributing to cognitive decline and Alzheimer's disease (AD). Treadmill running is considered to be a critical approach for mice and rats to lower blood sugar and improve learning and memory capacity. The growth factor receptor-bound protein 10 (Grb10) has been proposed to inhibit insulin signaling and defective brain insulin signaling resulted in the cognitive deficits in patients with AD. However, the positive roles of treadmill training on diabetic- related impaired cognitive function and their molecular mechanisms remain unclear. Here, to investigate whether there was neuroprotective effects of treadmill training on impaired cognitive function caused by diabetes, the rats were injected intraperitoneally with streptozotocin at a dose of 30 mg/kg to establish diabetic model (DM). We found that higher Grb10, BACE1 and PHF10 protein levels in the hippocampus of DM rats, lower phosphorylation IGF-1Rβ and IRS-1( <superscript>ser307</superscript> ). However, 8 weeks treadmill training effectively reduced abnormal Grb10, enhanced postsynaptic density protein PSD-93, PSD-95, SYN expressions of hippocampus, restored PI3K/Akt/ERK and mTOR/AMPK signaling, thus alleviated spatial learning and memory deficit, compared with DM group. Additionally, treadmill training also increased GLUT4 transportation. Overall, our findings suggest that treadmill intervention improved cognitive impairments caused by diabetes disease partly through modulating Grb10/ PI3K/Akt/ERK as well as mTOR/AMPK signaling.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antibiotics, Antineoplastic administration & dosage
Cognitive Dysfunction chemically induced
Cognitive Dysfunction metabolism
Diabetes Complications chemically induced
Diabetes Complications metabolism
Diabetes Mellitus, Experimental chemically induced
Diabetes Mellitus, Experimental metabolism
Diabetes Mellitus, Type 2 chemically induced
Diabetes Mellitus, Type 2 metabolism
Rats
Streptozocin administration & dosage
Cognitive Dysfunction therapy
Diabetes Complications therapy
Diabetes Mellitus, Experimental complications
Diabetes Mellitus, Type 2 complications
Exercise Therapy
GRB10 Adaptor Protein metabolism
Glucose Transporter Type 4 drug effects
Physical Conditioning, Animal physiology
Running physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2747
- Volume :
- 181
- Database :
- MEDLINE
- Journal :
- Brain research bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 35065184
- Full Text :
- https://doi.org/10.1016/j.brainresbull.2022.01.007