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Experimental mapping of short-wavelength phonons in proteins.
- Source :
-
Innovation (Cambridge (Mass.)) [Innovation (Camb)] 2021 Dec 17; Vol. 3 (1), pp. 100199. Date of Electronic Publication: 2021 Dec 17 (Print Publication: 2022). - Publication Year :
- 2021
-
Abstract
- Phonons are quasi-particles, observed as lattice vibrations in periodic materials, that often dampen in the presence of structural perturbations. Nevertheless, phonon-like collective excitations exist in highly complex systems, such as proteins, although the origin of such collective motions has remained elusive. Here we present a picture of temperature and hydration dependence of collective excitations in green fluorescent protein (GFP) obtained by inelastic neutron scattering. Our results provide evidence that such excitations can be used as a measure of flexibility/softness and are possibly associated with the protein's activity. Moreover, we show that the hydration water in GFP interferes with the phonon propagation pathway, enhancing the structural rigidity and stability of GFP.<br />Competing Interests: The authors declare no competing interests.<br /> (© 2021 The Author(s).)
Details
- Language :
- English
- ISSN :
- 2666-6758
- Volume :
- 3
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Innovation (Cambridge (Mass.))
- Publication Type :
- Academic Journal
- Accession number :
- 35059681
- Full Text :
- https://doi.org/10.1016/j.xinn.2021.100199