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Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity.
- Source :
-
International journal of ophthalmology [Int J Ophthalmol] 2022 Jan 18; Vol. 15 (1), pp. 106-112. Date of Electronic Publication: 2022 Jan 18 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Aim: To evaluate foveal vessel density (VD) and foveal thickness using optical coherence tomography angiography (OCTA) in retinopathy of prematurity (ROP) children treated with laser photocoagulation or anti-vascular endothelial growth factor (VEGF) injection. Additionally, we assessed the relationship between foveal microvascular anomalies and different therapies in ROP children.<br />Methods: This was a single-center, retrospective study of patients with a diagnosis of type 1 ROP. Twenty-three eyes (14 patients) treated with anti-VEGF injection and twenty-nine eyes (17 patients) treated with laser coagulation were included in this study. The foveal VD, inner thickness and full thickness were measured at the central 0°, 2° to 8°, and 8° of the retina (centered on the fovea) using OCTA and cross-sectional OCT, respectively.<br />Results: Foveal VD, inner thickness and full thickness were significantly smaller within the central 8° of the retina in ROP children treated with anti-VEGF injection than in those treated with laser photocoagulation ( P =0.013, 0.009, 0.036, respectively). The full thickness was also smaller in the anti-VEGF group than in the laser group at the central 0° of the retina ( P =0.010). The grade of foveal hypoplasia is lower in the anti-VEGF group than in the laser group ( P =0.045). Multivariable analysis did not find any risk factors associated with visual acuity in our study.<br />Conclusion: In children with type 1 ROP, the better structural development of fovea in those who were treated with anti-VEGF injection compared with laser photocoagulation are identified. However, visual acuity outcomes are similar 70mo after the treatments.<br /> (International Journal of Ophthalmology Press.)
Details
- Language :
- English
- ISSN :
- 2222-3959
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 35047364
- Full Text :
- https://doi.org/10.18240/ijo.2022.01.16