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Dose-dependent effect of myelin oligodendrocyte glycoprotein on visual function and optic nerve damage in experimental autoimmune encephalomyelitis.

Authors :
Castoldi V
Marenna S
Huang SC
d'Isa R
Chaabane L
Comi G
Leocani L
Source :
Journal of neuroscience research [J Neurosci Res] 2022 Mar; Vol. 100 (3), pp. 855-868. Date of Electronic Publication: 2022 Jan 18.
Publication Year :
2022

Abstract

Female Dark Agouti rats were immunized with increasing doses of myelin oligodendrocyte glycoprotein (MOG) to develop experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis. Typical EAE motor impairments were assessed daily and noninvasive visual evoked potentials (VEPs) were recorded at baseline and 5 weeks after immunization, with final histopathology of optic nerves (ONs). Immunized rats exhibited a relapsing-remitting clinical course. Both VEP and histological abnormalities were detected in a MOG dose-dependent gradient. Increasing MOG dosage augmented visual function impairment in EAE, which could be monitored with VEP recording to assess demyelination and axonal loss along ONs.<br /> (© 2022 Wiley Periodicals LLC.)

Details

Language :
English
ISSN :
1097-4547
Volume :
100
Issue :
3
Database :
MEDLINE
Journal :
Journal of neuroscience research
Publication Type :
Academic Journal
Accession number :
35043454
Full Text :
https://doi.org/10.1002/jnr.25007