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Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa.
- Source :
-
Nature [Nature] 2022 Mar; Vol. 603 (7902), pp. 679-686. Date of Electronic Publication: 2022 Jan 07. - Publication Year :
- 2022
-
Abstract
- The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (B.1.351) and Delta (B.1.617.2) variants, respectively <superscript>1-3</superscript> . In November 2021, genomic surveillance teams in South Africa and Botswana detected a new SARS-CoV-2 variant associated with a rapid resurgence of infections in Gauteng province, South Africa. Within three days of the first genome being uploaded, it was designated a variant of concern (Omicron, B.1.1.529) by the World Health Organization and, within three weeks, had been identified in 87 countries. The Omicron variant is exceptional for carrying over 30 mutations in the spike glycoprotein, which are predicted to influence antibody neutralization and spike function <superscript>4</superscript> . Here we describe the genomic profile and early transmission dynamics of Omicron, highlighting the rapid spread in regions with high levels of population immunity.<br /> (© 2022. The Author(s).)
- Subjects :
- Antibodies, Neutralizing immunology
Botswana epidemiology
COVID-19 immunology
COVID-19 transmission
Humans
Models, Molecular
Mutation
Phylogeny
Recombination, Genetic
SARS-CoV-2 classification
SARS-CoV-2 immunology
South Africa epidemiology
Spike Glycoprotein, Coronavirus genetics
Spike Glycoprotein, Coronavirus immunology
COVID-19 epidemiology
COVID-19 virology
Immune Evasion
SARS-CoV-2 isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 603
- Issue :
- 7902
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 35042229
- Full Text :
- https://doi.org/10.1038/s41586-022-04411-y