[Comparative chemoreactome analysis of the synergism of vinpocetine, piracetam, and cinnarizine molecules].

Objective: Neuroprotective and nootropic drugs often exhibit complementary, «synergistic» effects, the consideration of which is important for choosing the most effective and safe drug combinations.
Material and Methods: Chemoinformatic analysis of vinpocetine, piracetam and cinnarizine on neuron cultures, on model organisms (mice, rats) based on modern data mining and machine learning methods.
Results: The paper presents the results of the chemoreactom analysis of vinpocetine, piracetam, and cinnarizine. Estimates of various biological activities of molecules on neuronal cultures, on model organisms (mice, rats) and estimates of modulation of the activity of target proteins in rats and humans were obtained. The data obtained made it possible to quantify the value of the synergism score for the combination «vinpocetine + piracetam» (54 points) compared with the combination «piracetam + cinnarizine» (25 points).
Conclusions: The combination of «vinpocetine + piracetam» in the fixed combination (Vinpotropil) is thus more preferable for combined use than for the combination of «piracetam + cinnarizine».