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Testosterone supplementation and bone parameters: a systematic review and meta-analysis study.
- Source :
-
Journal of endocrinological investigation [J Endocrinol Invest] 2022 May; Vol. 45 (5), pp. 911-926. Date of Electronic Publication: 2022 Jan 18. - Publication Year :
- 2022
-
Abstract
- Background: The role of testosterone (T) replacement therapy (TRT) in subjects with late onset hypogonadism is still the object of an intense debate.<br />Methods: All observational studies and placebo-controlled or -uncontrolled randomized trials (RCTs) comparing the effect of TRT on different bone parameters were considered.<br />Results: Out of 349 articles, 36 were considered, including 3103 individuals with a mean trial duration of 66.6 weeks. TRT improves areal bone mineral density (aBMD) at the spine and femoral neck levels in observational studies, whereas placebo-controlled RTCs showed a positive effect of TRT only at lumber spine and when trials included only hypogonadal patients at baseline (total testosterone < 12 nM). The effects on aBMD were more evident in subjects with lower T levels at baseline and increased as a function of trial duration and a higher prevalence of diabetic subjects. Either T or estradiol increase at endpoint contributed to aBMD improvement. TRT was associated with a significant reduction of bone resorption markers in observational but not in controlled studies.<br />Conclusion: TRT is able to inhibit bone resorption and increase bone mass, particularly at the lumbar spine level and when the duration is long enough to allow the anabolic effect of T and estrogens on bone metabolism to take place.<br /> (© 2022. Italian Society of Endocrinology (SIE).)
Details
- Language :
- English
- ISSN :
- 1720-8386
- Volume :
- 45
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of endocrinological investigation
- Publication Type :
- Academic Journal
- Accession number :
- 35041193
- Full Text :
- https://doi.org/10.1007/s40618-021-01702-5