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Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine-elicited human sera.
- Source :
-
Science (New York, N.Y.) [Science] 2022 Feb 11; Vol. 375 (6581), pp. 678-680. Date of Electronic Publication: 2022 Jan 18. - Publication Year :
- 2022
-
Abstract
- The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number of mutations, especially in the spike protein, indicating that recognition by neutralizing antibodies may be compromised. We tested Wuhan (Wuhan-Hu-1 reference strain), Beta (B.1.351), Delta (B.1.617.2), or Omicron pseudoviruses with sera of 51 participants who received two or three doses of the messenger RNA (mRNA)-based COVID-19 vaccine BNT162b2. After two doses, Omicron-neutralizing titers were reduced >22-fold compared with Wuhan-neutralizing titers. One month after the third vaccine dose, Omicron-neutralizing titers were increased 23-fold relative to their levels after two doses and were similar to levels of Wuhan-neutralizing titers after two doses. The requirement of a third vaccine dose to effectively neutralize Omicron was confirmed with sera from a subset of participants using live SARS-CoV-2. These data suggest that three doses of the mRNA vaccine BNT162b2 may protect against Omicron-mediated COVID-19.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Neutralizing blood
Antibodies, Viral blood
BNT162 Vaccine administration & dosage
COVID-19 virology
COVID-19 Vaccines administration & dosage
Humans
Immunization Schedule
Immunization, Secondary
Middle Aged
Mutation
Neutralization Tests
Spike Glycoprotein, Coronavirus genetics
Spike Glycoprotein, Coronavirus immunology
T-Lymphocytes immunology
Vaccination
Young Adult
Antibodies, Neutralizing immunology
Antibodies, Viral immunology
BNT162 Vaccine immunology
COVID-19 prevention & control
COVID-19 Vaccines immunology
SARS-CoV-2 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 375
- Issue :
- 6581
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 35040667
- Full Text :
- https://doi.org/10.1126/science.abn7591