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Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization.
- Source :
-
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2022 Jan 03; Vol. 63 (1), pp. 20. - Publication Year :
- 2022
-
Abstract
- Purpose: The local growth rates of geographic atrophy (GA) adjacent to non-exudative type 1 macular neovascularization (MNV) were investigated to determine if MNV influenced GA growth.<br />Methods: Eyes with GA and non-exudative type 1 MNV were followed for at least 1 year. Both GA and the MNV were imaged and measured using swept-source optical coherence tomography angiography (SS-OCTA) scans. Pearson correlations were computed between local growth rates of GA, which were estimated using a biophysical GA growth model, and local distances-to-MNV. Corresponding P values for the null hypothesis of no Pearson correlation were computed using a Monte Carlo approach that adjusts for spatial autocorrelations.<br />Results: Nine eyes were included in this study. There were positive correlations (Pearson's r > 0) between distance-to-MNV and local GA growth in eight (89%) of the eyes; however, in all but one eye (11%), correlations were relatively weak and statistically nonsignificant after Bonferroni correction (corrected P > 0.05).<br />Conclusions: SS-OCTA imaging combined with GA growth modeling and spatial statistical analysis enabled quantitative assessment of correlations between local GA growth rates and local distances-to-MNV. Our results are not consistent with non-exudative type 1 MNV having a strong inhibitory effect on local GA growth rates.
- Subjects :
- Aged
Aged, 80 and over
Female
Fundus Oculi
Geographic Atrophy diagnosis
Humans
Incidence
Male
Prospective Studies
Retinal Neovascularization diagnosis
United States epidemiology
Fluorescein Angiography methods
Geographic Atrophy epidemiology
Macula Lutea diagnostic imaging
Retinal Neovascularization epidemiology
Tomography, Optical Coherence methods
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5783
- Volume :
- 63
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Investigative ophthalmology & visual science
- Publication Type :
- Academic Journal
- Accession number :
- 35029635
- Full Text :
- https://doi.org/10.1167/iovs.63.1.20