Back to Search Start Over

Emerging roles of CD133 in the treatment of gastric cancer, a novel stem cell biomarker and beyond.

Authors :
Soleimani A
Dadjoo P
Avan A
Soleimanpour S
Rajabian M
Ferns G
Ryzhikov M
Khazaei M
Hassanian SM
Source :
Life sciences [Life Sci] 2022 Mar 15; Vol. 293, pp. 120050. Date of Electronic Publication: 2022 Jan 10.
Publication Year :
2022

Abstract

Gastric cancer (GC) is an aggressive disease with one of the highest mortality rates in the world. In the early stage, most patients are asymptomatic and early diagnosis is difficult. Recently, cancer stem cells (CSCs) have been highlighted as crucial emerging factors in the initiation or invasiveness of solid tumors. CD133, a CSC marker, is highly expressed in various tumors including gastric cancer. CD133-positive cells showed elevated malignant biological behaviors and CD133 upregulation is related to chemoresistance, cancer relapse, and poor prognosis. CD133 also plays an important role in the progression of tumors and metastasis. This review summarizes the current knowledge of the role of CD133 expression in GC and aims to contribute at identifying promising new strategies for treatment and management of gastric cancer.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1879-0631
Volume :
293
Database :
MEDLINE
Journal :
Life sciences
Publication Type :
Academic Journal
Accession number :
35026215
Full Text :
https://doi.org/10.1016/j.lfs.2021.120050