Back to Search
Start Over
Paediatric osteoarticular infections caused by staphylococcus aureus producing panton-valentine leucocidin in morocco: Risk factors and clinical features.
- Source :
-
African journal of paediatric surgery : AJPS [Afr J Paediatr Surg] 2022 Apr-Jun; Vol. 19 (2), pp. 78-82. - Publication Year :
- 2022
-
Abstract
- Objective: We aimed to estimate the prevalence of Staphylococcus aureus producing Panton-Valentine leucocidin (PVL) isolated from children diagnosed with osteoarticular infections (OAIs), and to examine risk factors and clinical features.<br />Methods: This prospective study was conducted from January 2017 to December 2018. All hospitalised children diagnosed with S. aureus OAI are included. Blood cultures, articular fluids, synovial tissues and/or bone fragments were collected for bacteriological culture. Antimicrobial susceptibility tests were determined by disk diffusion method. Genes encoding methicillin resistance (mecA) and PVL virulence factors (luk-S-PV and luk-F-PV) were detected by multiplex polymerase chain reaction. The demographic, clinical, laboratory, radiographic and clinical features were reviewed prospectively from medical records.<br />Results: A total of 37 children with S. aureus OAIs were included, 46% of them have PVL-positive infection and 70.6% were male. The mean age was 8.12 years (±4.57), and almost were from rural settings (76.5%). Children with Staphylococcus aureus producing Panton-Valentine leucocidin (SA-PVL) were significantly associated with type of infection (P = 0.005), location of infection (P = 0.037) and abnormal X-ray (P = 0.029). All strains SA-PVL+ are sensitive to methicillin, but one strain SA-PVL negative was methicillin-resistant S. aureus, confirmed by gene mecA positive.<br />Conclusion: The prevalence of S. aureus infections producing PVL toxin was high in OAIs amongst Moroccan children, mainly due to methicillin-susceptible S. aureus. Type and location of infections and abnormal X-ray were significantly associated with SA-PVL. Routine diagnostic testing of PVL-SA, continuous epidemiological surveillance and multidisciplinary management of OAI is essential to prevent serious complications.<br />Competing Interests: None
- Subjects :
- Bone Diseases, Infectious microbiology
Child
Child, Preschool
Female
Humans
Leukocidins genetics
Male
Morocco epidemiology
Prospective Studies
Risk Factors
Staphylococcus aureus
Bone Diseases, Infectious epidemiology
Methicillin-Resistant Staphylococcus aureus
Staphylococcal Infections diagnosis
Staphylococcal Infections drug therapy
Staphylococcal Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0974-5998
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- African journal of paediatric surgery : AJPS
- Publication Type :
- Academic Journal
- Accession number :
- 35017376
- Full Text :
- https://doi.org/10.4103/ajps.AJPS_18_21