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Sweet Immune Checkpoint Targets to Enhance T Cell Therapy.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Jan 15; Vol. 208 (2), pp. 278-285. - Publication Year :
- 2022
-
Abstract
- Despite tremendous success against hematological malignancies, the performance of chimeric Ag receptor T cells against solid tumors remains poor. In such settings, the lack of success of this groundbreaking immunotherapy is in part mediated by ligand engagement of immune checkpoint molecules on the surface of T cells in the tumor microenvironment. Although CTLA-4 and programmed death-1 (PD-1) are well-established checkpoints that inhibit T cell activity, the engagement of glycans and glycan-binding proteins are a growing area of interest due to their immunomodulatory effects. This review discusses exemplary strategies to neutralize checkpoint molecules through an in-depth overview of genetic engineering approaches aimed at overcoming the inhibitory programmed death ligand-1 (PD-L1)/PD-1 axis in T cell therapies and summarizes current knowledge on glycoimmune interactions that mediate T cell immunosuppression.<br /> (Copyright © 2022 by The American Association of Immunologists, Inc.)
- Subjects :
- CTLA-4 Antigen metabolism
Cell- and Tissue-Based Therapy methods
Galectin 1 immunology
Galectin 3 immunology
Galectins immunology
Humans
Immunomodulation immunology
Lymphocyte Activation immunology
Neoplasms immunology
Polysaccharides metabolism
Programmed Cell Death 1 Receptor antagonists & inhibitors
Programmed Cell Death 1 Receptor metabolism
Receptors, Chimeric Antigen immunology
T-Lymphocytes immunology
Tumor Microenvironment immunology
B7-H1 Antigen antagonists & inhibitors
CTLA-4 Antigen immunology
Immunotherapy, Adoptive methods
Neoplasms therapy
Programmed Cell Death 1 Receptor immunology
T-Lymphocytes transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 208
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 35017217
- Full Text :
- https://doi.org/10.4049/jimmunol.2100706