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Efficacy of mupirocin, neomycin and octenidine for nasal Staphylococcus aureus decolonisation: a retrospective cohort study.
- Source :
-
Antimicrobial resistance and infection control [Antimicrob Resist Infect Control] 2022 Jan 10; Vol. 11 (1), pp. 5. Date of Electronic Publication: 2022 Jan 10. - Publication Year :
- 2022
-
Abstract
- Background: Periprosthetic joint infection (PJI) causes significant morbidity. Methicillin sensitive Staphylococcus aureus (MSSA) is the most frequent organism, and the majority are endogenous. Decolonisation reduces PJIs but there is a paucity of evidence comparing treatments. Aims; compare 3 nasal decolonisation treatments at (1) achieving MSSA decolonisation, (2) preventing PJI.<br />Methods: Our hospital prospectively collected data on our MSSA decolonisation programme since 2013, including; all MSSA carriers, treatment received, MSSA status at time of surgery and all PJIs. Prior to 2017 MSSA carriers received nasal mupirocin or neomycin, from August 2017 until August 2019 nasal octenidine was used.<br />Results: During the study period 15,958 primary hip and knee replacements were performed. 3200 (20.1%) were MSSA positive at preoperative screening and received decolonisation treatment, 698 mupirocin, 1210 neomycin and 1221 octenidine. Mupirocin (89.1%) and neomycin (90.9%) were more effective at decolonisation than octenidine (50.0%, Pā<ā0.0001). There was no difference in PJI rates (Pā=ā0.452).<br />Conclusions: Mupirocin and neomycin are more effective than octenidine at MSSA decolonisation. There was poor correlation between the MSSA status after treatment (on day of surgery) and PJI rates. Further research is needed to compare alternative MSSA decolonisation treatments.<br /> (© 2021. The Author(s).)
- Subjects :
- Anti-Infective Agents, Local therapeutic use
Cohort Studies
Drug Resistance, Bacterial
England
Joint Diseases microbiology
Joint Diseases prevention & control
Methicillin pharmacology
Nose Diseases microbiology
Retrospective Studies
Staphylococcal Infections microbiology
Staphylococcus aureus drug effects
Staphylococcus aureus physiology
Anti-Bacterial Agents therapeutic use
Imines therapeutic use
Mupirocin therapeutic use
Neomycin therapeutic use
Nose Diseases prevention & control
Pyridines therapeutic use
Staphylococcal Infections prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 2047-2994
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Antimicrobial resistance and infection control
- Publication Type :
- Academic Journal
- Accession number :
- 35012641
- Full Text :
- https://doi.org/10.1186/s13756-021-01043-1