Back to Search
Start Over
[HLA and molar pregnancies (triploidies, hydatidiform moles and choriocarcinoma). Etiological and epidemiological study].
- Source :
-
Annales de genetique [Ann Genet] 1987; Vol. 30 (4), pp. 197-208. - Publication Year :
- 1987
-
Abstract
- Etiological and epidemiological studies of triploid and hydatidiform molar conceptuses were done using HLA polymorphism. The segregation of HLA markers allowed to know the etiology of 25 triploidies and 19 hydatidiform moles. Five other moles and a post molar choriocarcinoma were also studied by molecular hybridization. This confirms that triploidies in about 3/4 of the cases involved two sets of paternal chromosomes mainly by di-sperm. Hydatidiform moles from Algeria, France and Senegal were all of androgenic origin excepted for one case. DNA analysis of the choriocarcinoma demonstrated the presence of a paternal marker suggesting for this case a direct cellular lineage from the mole. Positive associations with HLA A 28 and B 7 were found which could be related to gametogenesis-fecundation dysfunction. A slight excess of antigens shared by parents of triploidies was shown. This was not observed for parents of hydatidiform moles but when they shared HLA antigens a preferential inheritance in the mole of the shared specificities was observed. This relative compatibility of the molar conceptus with the mother may be an element of the process that prevent its early rejection.
- Subjects :
- Choriocarcinoma epidemiology
Choriocarcinoma etiology
Choriocarcinoma genetics
Female
France
HLA Antigens analysis
Humans
Hydatidiform Mole epidemiology
Hydatidiform Mole etiology
Hydatidiform Mole genetics
Male
Polymorphism, Genetic
Pregnancy
Uterine Neoplasms epidemiology
Uterine Neoplasms etiology
Uterine Neoplasms genetics
Choriocarcinoma immunology
HLA Antigens genetics
Hydatidiform Mole immunology
Polyploidy
Uterine Neoplasms immunology
Subjects
Details
- Language :
- French
- ISSN :
- 0003-3995
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annales de genetique
- Publication Type :
- Academic Journal
- Accession number :
- 3501264