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Nano-Organization at the Synapse: Segregation of Distinct Forms of Neurotransmission.
- Source :
-
Frontiers in synaptic neuroscience [Front Synaptic Neurosci] 2021 Dec 22; Vol. 13, pp. 796498. Date of Electronic Publication: 2021 Dec 22 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Synapses maintain synchronous, asynchronous, and spontaneous modes of neurotransmission through distinct molecular and biochemical pathways. Traditionally a single synapse was assumed to have a homogeneous organization of molecular components both at the active zone and post-synaptically. However, recent advancements in experimental tools and the further elucidation of the physiological significance of distinct forms of release have challenged this notion. In comparison to rapid evoked release, the physiological significance of both spontaneous and asynchronous neurotransmission has only recently been considered in parallel with synaptic structural organization. Active zone nanostructure aligns with postsynaptic nanostructure creating a precise trans-synaptic alignment of release sites and receptors shaping synaptic efficacy, determining neurotransmission reliability, and tuning plasticity. This review will discuss how studies delineating synaptic nanostructure create a picture of a molecularly heterogeneous active zone tuned to distinct forms of release that may dictate diverse synaptic functional outputs.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Guzikowski and Kavalali.)
Details
- Language :
- English
- ISSN :
- 1663-3563
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Frontiers in synaptic neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 35002671
- Full Text :
- https://doi.org/10.3389/fnsyn.2021.796498