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Circulating Cell-Free Mitochondrial DNA in Pregnancy.

Authors :
Bradshaw JL
Cushen SC
Phillips NR
Goulopoulou S
Source :
Physiology (Bethesda, Md.) [Physiology (Bethesda)] 2022 Jul 01; Vol. 37 (4), pp. 0. Date of Electronic Publication: 2022 Jan 10.
Publication Year :
2022

Abstract

Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.

Subjects

Subjects :
DNA, Mitochondrial genetics
DNA, Mitochondrial metabolism
Female
Humans
Inflammation metabolism
Pregnancy
Cell-Free Nucleic Acids genetics
Cell-Free Nucleic Acids metabolism
Mitochondria metabolism

Details

Language :
English
ISSN :
1548-9221
Volume :
37
Issue :
4
Database :
MEDLINE
Journal :
Physiology (Bethesda, Md.)
Publication Type :
Academic Journal
Accession number :
35001655
Full Text :
https://doi.org/10.1152/physiol.00037.2021
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