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Association of tumor necrosis factor-α inhibitors and liver cirrhosis in patients with rheumatoid arthritis: A nationwide population-based nested case-control study.
- Source :
-
International journal of rheumatic diseases [Int J Rheum Dis] 2022 Mar; Vol. 25 (3), pp. 327-334. Date of Electronic Publication: 2022 Jan 07. - Publication Year :
- 2022
-
Abstract
- Aim: Results from various studies are controversial regarding long-term hepatic effects of tumor necrosis factor (TNF)-α inhibitors. Here we aimed to investigate the development of liver cirrhosis with TNF-α inhibitors use in patients with rheumatoid arthritis (RA).<br />Method: This nested case-control study was based on the National Health Insurance Research Database (January 1, 2000 to December 31, 2008) of Taiwan. We identified 559 adult RA patients who developed liver cirrhosis, and 1055 matched control RA patients. TNF-α inhibitors of interest in the study period included adalimumab and etanercept. Multivariate logistic regression analysis for the development of liver cirrhosis with respect to use of TNF-α inhibitors was performed.<br />Results: The incidence rate of liver cirrhosis was 274 per 100 000 person-years in newly diagnosed RA patients. We found the use of TNF-α inhibitors was not associated with the development of liver cirrhosis in RA patients (odds ratio 1.02, 95% confidence interval 0.61, 1.70) after adjustment for potential confounders. In addition, the finding was robust to an unobserved confounder.<br />Conclusion: We found no association between the use of TNF-α inhibitors and development of liver cirrhosis in RA patients.<br /> (© 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adalimumab therapeutic use
Arthritis, Rheumatoid blood
Arthritis, Rheumatoid complications
Case-Control Studies
Etanercept therapeutic use
Female
Follow-Up Studies
Humans
Immunosuppressive Agents adverse effects
Immunosuppressive Agents therapeutic use
Incidence
Liver Cirrhosis diagnosis
Liver Cirrhosis epidemiology
Male
Middle Aged
Risk Factors
Taiwan epidemiology
Time Factors
Tumor Necrosis Factor Inhibitors adverse effects
Tumor Necrosis Factor Inhibitors therapeutic use
Ultrasonography
Adalimumab adverse effects
Arthritis, Rheumatoid drug therapy
Etanercept adverse effects
Liver Cirrhosis chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1756-185X
- Volume :
- 25
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of rheumatic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 34994523
- Full Text :
- https://doi.org/10.1111/1756-185X.14272