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Synthesis of 2,2-Difluoro-3-hydroxy-1,4-diketones via an HFIP-Catalyzed Mukaiyama Aldol Reaction of Glyoxal Monohydrates with Difluoroenoxysilanes.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2022 Jan 21; Vol. 87 (2), pp. 1144-1153. Date of Electronic Publication: 2022 Jan 07. - Publication Year :
- 2022
-
Abstract
- A novel efficient HFIP-catalyzed synthesis of structurally diverse 2,2-difluoro-3-hydroxy-1,4-diketone derivatives from readily available glyoxal monohydrates and difluoroenoxysilanes is described. This convenient protocol is induced by the distinctive fluorine effect of the reactants and the fluoroalcohol catalyst, which represents the first application of fluoroalcohol catalysis in a Mukaiyama aldol reaction.
- Subjects :
- Aldehydes
Catalysis
Molecular Structure
Stereoisomerism
Glyoxal
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 87
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34994195
- Full Text :
- https://doi.org/10.1021/acs.joc.1c02504