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Perfluorocarbon Nanoemulsions Enhance Therapeutic siRNA Delivery in the Treatment of Pulmonary Fibrosis.

Authors :
Ding L
Tang S
Tang W
Mosley DD
Yu A
Sil D
Romanova S
Bailey KL
Knoell DL
Wyatt TA
Oupický D
Source :
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Mar; Vol. 9 (8), pp. e2103676. Date of Electronic Publication: 2022 Jan 07.
Publication Year :
2022

Abstract

Local pulmonary administration of therapeutic siRNA represents a promising approach to the treatment of lung fibrosis, which is currently hampered by inefficient delivery. Development of perfluorooctylbromide (PFOB) nanoemulsions as a way of improving the efficiency of pulmonary polycation-based delivery of siRNA is reported. The results show that the polycation/siRNA/PFOB nanoemulsions are capable of efficiently silencing the expression of STAT3 and inhibiting chemokine receptor CXCR4-two validated targets in pulmonary fibrosis. Both in vitro and in vivo results demonstrate that the nanoemulsions improve mucus penetration and facilitate effective cellular delivery of siRNA. Pulmonary treatment of mice with bleomycin-induced pulmonary fibrosis shows strong inhibition of the progression of the disease and significant prolongation of animal survival. Overall, the study points to a promising local treatment strategy of pulmonary fibrosis.<br /> (© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.)

Details

Language :
English
ISSN :
2198-3844
Volume :
9
Issue :
8
Database :
MEDLINE
Journal :
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Publication Type :
Academic Journal
Accession number :
34994102
Full Text :
https://doi.org/10.1002/advs.202103676