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A possible cytotoxicity inducer role of 5/9 positive lymphocytes infiltrating the liver in CAH patients.
- Source :
-
Clinical immunology and immunopathology [Clin Immunol Immunopathol] 1987 Nov; Vol. 45 (2), pp. 286-91. - Publication Year :
- 1987
-
Abstract
- The presence, in chronic active hepatitis (CAH) patients, of an inflammatory infiltrate basically composed of T lymphocytes suggested the hypothesis that these lymphocytes could play a role in the pathogenesis of the disease. The aim of this study has been to characterize, in a group of carefully selected CAH patients, the liver-infiltrating T lymphocyte, utilizing commercial monoclonal antibody (anti-Leu 1, anti-Leu 2a, anti-Leu 3a) and 5/9 monoclonal antibody that recognizes a further lymphocyte subset within T4 cells. Our data show that both T4 positive subpopulation and T8 positive subpopulation are represented in the infiltrate in the same ratio; furthermore the distribution of 5/9 positive lymphocytes is prevalent where the infiltrate is mainly composed of T8 positive lymphocytes. Moreover, there is a positive correlation between 5/9 positive cells in the liver and GPT and the patients with high percentages of infiltrating 5/9 positive lymphocytes show a low T4/T8 ratio with respect to patients with low percentages of 5/9 positive cells. These data support the hypothesis that 5/9 positive lymphocytes may present an inducer role on cytotoxic cells.
- Subjects :
- Adult
Aged
Antigens, Differentiation, T-Lymphocyte analysis
Cytotoxicity, Immunologic
Female
Hepatitis B immunology
Hepatitis B pathology
Hepatitis, Chronic pathology
Humans
Leukocyte Count
Male
Middle Aged
T-Lymphocytes classification
T-Lymphocytes immunology
Hepatitis, Chronic immunology
Liver pathology
T-Lymphocytes pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0090-1229
- Volume :
- 45
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical immunology and immunopathology
- Publication Type :
- Academic Journal
- Accession number :
- 3499278
- Full Text :
- https://doi.org/10.1016/0090-1229(87)90043-2