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Cassane-type diterpenes from roots of Pterolobium macropterum and their anti-inflammatory activity.
- Source :
-
Phytochemistry [Phytochemistry] 2022 Apr; Vol. 196, pp. 113074. Date of Electronic Publication: 2022 Jan 03. - Publication Year :
- 2022
-
Abstract
- Eight undescribed cassane diterpenes, pterolobirins C-J, together with two known analogs, were isolated from the roots of Pterolobium macropterum. Their structures were characterized by extensive spectroscopic techniques including NMR, MS, ECD and X-ray crystallographic spectroscopy. The absolute configuration of pterolobirin J was confirmed by single-crystal X-ray diffraction data. The compounds were screened for their anti-inflammatory activity on the lipopolysaccharide (LPS) induced nitric oxide (NO) production in J774. A1 macrophage cells. Pterolobirin E and sucutinirane C displayed good NO inhibition with IC <subscript>50</subscript> values of 24.44 ± 1.34 and 19.16 ± 1.22 μM, respectively.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 196
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34990974
- Full Text :
- https://doi.org/10.1016/j.phytochem.2021.113074