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Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine.
- Source :
-
PloS one [PLoS One] 2022 Jan 05; Vol. 17 (1), pp. e0262225. Date of Electronic Publication: 2022 Jan 05 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase in disease caused by non-vaccine serotypes. To describe pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine (PCV-13) in July 2012, we performed molecular serotyping of 268 pneumococcal strains isolated from 221 children between 2012 and 2017. The median (interquartile range) age of the children included in this analysis was 6 (3,12) months. Fifty-nine percent of the children had received at least one dose of PCV-13 and 35% were fully vaccinated with PCV-13. While colonization by vaccine serotypes steadily declined following PCV-13 introduction, 25% of strains isolated more than 3 years after vaccine introduction were PCV-13 serotypes. We also observed an increase in colonization by non-vaccine serotypes 21 and 23B, which have been associated with invasive pneumococcal disease and antibiotic resistance in other settings.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Bacterial Typing Techniques
Botswana epidemiology
Female
Humans
Infant
Male
Nasopharynx microbiology
Phylogeny
Pneumococcal Infections epidemiology
Pneumococcal Infections microbiology
Pneumococcal Vaccines pharmacology
Population Surveillance
Streptococcus pneumoniae drug effects
Streptococcus pneumoniae genetics
Pneumococcal Infections prevention & control
Pneumococcal Vaccines administration & dosage
Serotyping methods
Streptococcus pneumoniae classification
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 34986196
- Full Text :
- https://doi.org/10.1371/journal.pone.0262225