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Design and evaluation of Raman reporters for the Raman-silent region.

Authors :: Plakas K
Rosch LE
Clark MD
Adbul-Rashed S
Shaffer TM
Harmsen S
Gambhir SS
Detty MR
Source :: Nanotheranostics [Nanotheranostics] 2022 Jan 01; Vol. 6 (1), pp. 1-9. Date of Electronic Publication: 2022 Jan 01 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Rationale: Surface enhanced Raman scattering (SERS) is proving to be a useful tool for biomedical imaging. However, this imaging technique can suffer from poor signal-to-noise ratio, as the complexity of biological tissues can lead to overlapping of Raman bands from tissues and the Raman reporter molecule utilized. Methods: Herein we describe the synthesis of triple bond containing Raman reporters that scatter light in the biological silent window, between 1750 cm <superscript>-1</superscript> and 2750 cm <superscript>-1</superscript> . Results: Our SERS nanoprobes are comprised of uniquely designed Raman reporters containing either alkyne- or cyano-functional groups, enabling them to be readily distinguished from background biological tissue. Conclusion: We identify promising candidates that eventually can be moved forward as Raman reporters in SERS nanoparticles for highly specific contrast-enhanced Raman-based disease or analyte detection in biological applications.<br />Competing Interests: Competing Interests: Stefan Harmsen is listed as inventor on several patents related to the SERS technology used in this work. Sanjiv Sam Gambhir holds the original patent on the use of SERS in living subjects.<br /> (© The author(s).)