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Prone Positioning in Patients With COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2022 Jan-Feb; Vol. 36 (1), pp. 361-370. - Publication Year :
- 2022
-
Abstract
- Background/aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19.<br />Materials and Methods: Meta-analysis of individual (7 investigators' groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO <subscript>2</subscript> /FiO <subscript>2</subscript> ) in patients with COVID-19.<br />Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO <subscript>2</subscript> /FiO <subscript>2</subscript> difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=-0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO <subscript>2</subscript> /FiO <subscript>2</subscript> difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies.<br />Conclusion: PP seems to improve oxygenation of patients with COVID-19.<br /> (Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1791-7549
- Volume :
- 36
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 34972735
- Full Text :
- https://doi.org/10.21873/invivo.12711