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Association of Urinary Potassium Excretion with Blood Pressure Variability and Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease.
- Source :
-
Nutrients [Nutrients] 2021 Dec 13; Vol. 13 (12). Date of Electronic Publication: 2021 Dec 13. - Publication Year :
- 2021
-
Abstract
- Dietary potassium intake is a dilemma in patients with chronic kidney disease (CKD). We investigated the association of urine potassium excretion, a surrogate for dietary potassium intake, with blood pressure variability (BPV) and cardiovascular (CV) outcomes in patients with pre-dialysis CKD. A total of 1860 participants from a cohort of pre-dialysis CKD (KNOW-CKD) patients were divided into the quartiles by spot urine potassium-to-creatinine ratio. The first quartile (26.423 ± 5.731 mmol/gCr) was defined as low urine potassium excretion. Multivariate linear regression analyses revealed an independent association of low urine potassium excretion with high BPV (adjusted β coefficient 1.163, 95% confidence interval 0.424 to 1.901). Cox regression analyses demonstrated that, compared to high urine potassium excretion, low urine potassium excretion is associated with increased risk of CV events (adjusted hazard ratio 2.502, 95% confidence interval 1.162 to 5.387) but not with all-cause mortality. In conclusion, low urine potassium excretion is associated with high BPV and increased risk of CV events in patients with pre-dialysis CKD. The restriction of dietary potassium intake should be individualized in patients with pre-dialysis CKD.
- Subjects :
- Adult
Aged
Cardiovascular Diseases mortality
Cohort Studies
Creatinine urine
Dialysis methods
Female
Humans
Hypertension epidemiology
Male
Middle Aged
Potassium administration & dosage
Prospective Studies
Renal Insufficiency, Chronic epidemiology
Renal Insufficiency, Chronic mortality
Renal Insufficiency, Chronic physiopathology
Risk Factors
Sodium urine
Blood Pressure
Cardiovascular Diseases epidemiology
Potassium urine
Renal Insufficiency, Chronic urine
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 13
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 34959995
- Full Text :
- https://doi.org/10.3390/nu13124443