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B- and Plasma Cell Subsets in Autoimmune Diseases: Translational Perspectives.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 2022 Mar; Vol. 142 (3 Pt B), pp. 811-822. Date of Electronic Publication: 2021 Dec 24. - Publication Year :
- 2022
-
Abstract
- B lymphocytes play a central role in immunity owing to their unique antibody-producing capacity that provides protection against certain infections and during vaccination. In autoimmune diseases, B cells can gain pathogenic relevance through autoantibody production, antigen presentation, and proinflammatory cytokine secretion. Recent data indicate that B and plasma cells can function as regulators through the production of immunoregulatory cytokines and/or employing checkpoint molecules. In this study, we review the key findings that define subsets of B and plasma cells with pathogenic and protective functions in autoimmunity. In addition to harsh B-cell depletion, we discuss the strategies that have the potential to reinstall the balance of pathogenic and protective B cells with the potential of more specific and personalized therapies.<br /> (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Autoimmunity
B-Lymphocytes
Cytokines
Humans
Autoimmune Diseases
Plasma Cells
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1747
- Volume :
- 142
- Issue :
- 3 Pt B
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 34955289
- Full Text :
- https://doi.org/10.1016/j.jid.2021.05.038