Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening.

Subjects

Subjects :

Arrhythmias, Cardiac genetics
Brugada Syndrome genetics
Drug Evaluation, Preclinical methods
Drug Evaluation, Preclinical statistics & numerical data
Gene Editing methods
Gene Editing statistics & numerical data
Genetic Variation genetics
Genetic Variation physiology
Humans
Induced Pluripotent Stem Cells metabolism
Arrhythmias, Cardiac physiopathology
Brugada Syndrome physiopathology
Myocytes, Cardiac metabolism

Details

Language :

English

ISSN :

2001-1326

Volume :

11

Issue :

12

Database :

MEDLINE

Journal :

Clinical and translational medicine

Publication Type :

Report

Accession number :

34954893

Full Text :

https://doi.org/10.1002/ctm2.646